diff --git a/src/calibre/devices/libusb/libusb.c b/src/calibre/devices/libusb/libusb.c
index a4611367b2..4ec6b3b1e6 100644
--- a/src/calibre/devices/libusb/libusb.c
+++ b/src/calibre/devices/libusb/libusb.c
@@ -115,6 +115,8 @@ static PyObject* get_devices(PyObject *self, PyObject *args) {
     return ans;
 }
 
+static char libusb_doc[] = "Interface to libusb.";
+
 static PyMethodDef libusb_methods[] = {
     {"get_devices", get_devices, METH_VARARGS,
         "get_devices()\n\nGet the list of USB devices on the system."
@@ -123,26 +125,55 @@ static PyMethodDef libusb_methods[] = {
     {NULL, NULL, 0, NULL}
 };
 
-CALIBRE_MODINIT_FUNC
-initlibusb(void) {
+#if PY_MAJOR_VERSION >= 3
+#define INITERROR return NULL
+#define INITMODULE PyModule_Create(&libusb_module)
+static struct PyModuleDef libusb_module = {
+    /* m_base     */ PyModuleDef_HEAD_INIT,
+    /* m_name     */ "libusb",
+    /* m_doc      */ libusb_doc,
+    /* m_size     */ -1,
+    /* m_methods  */ libusb_methods,
+    /* m_slots    */ 0,
+    /* m_traverse */ 0,
+    /* m_clear    */ 0,
+    /* m_free     */ 0,
+};
+CALIBRE_MODINIT_FUNC PyInit_libusb(void) {
+#else
+#define INITERROR return
+#define INITMODULE Py_InitModule3("libusb", libusb_methods, libusb_doc)
+CALIBRE_MODINIT_FUNC initlibusb(void) {
+#endif
+
     PyObject *m;
 
     // We deliberately use the default context. This is the context used by
     // libmtp and we want to ensure that the busnum/devnum numbers are the same
     // here and for libmtp.
-    if(libusb_init(NULL) != 0) return;
+    if(libusb_init(NULL) != 0) {
+        INITERROR;
+    }
 
     Error = PyErr_NewException("libusb.Error", NULL, NULL);
-    if (Error == NULL) return;
+    if (Error == NULL) {
+        INITERROR;
+    }
 
     cache = PyDict_New();
-    if (cache == NULL) return;
+    if (cache == NULL) {
+        INITERROR;
+    }
 
-    m = Py_InitModule3("libusb", libusb_methods, "Interface to libusb.");
-    if (m == NULL) return;
+    m = INITMODULE;
+    if (m == NULL) {
+        INITERROR;
+    }
 
     PyModule_AddObject(m, "Error", Error);
     PyModule_AddObject(m, "cache", cache);
 
+#if PY_MAJOR_VERSION >= 3
+    return m;
+#endif
 }
-