diff --git a/src/calibre/gui2/ui.py b/src/calibre/gui2/ui.py
index a2ec8c9846..6766635789 100644
--- a/src/calibre/gui2/ui.py
+++ b/src/calibre/gui2/ui.py
@@ -463,6 +463,10 @@ class Main(MainWindow, MainWindowMixin, DeviceMixin, EmailMixin, # {{{
             self.card_a_view.reset()
             self.card_b_view.reset()
         self.device_manager.set_current_library_uuid(db.library_id)
+        # Run a garbage collection now so that it does not freeze the
+        # interface later
+        import gc
+        gc.collect()
 
 
     def set_window_title(self):