diff --git a/src/calibre/gui2/dialogs/quickview.py b/src/calibre/gui2/dialogs/quickview.py
index 14c218228f..a6e4c28d1d 100644
--- a/src/calibre/gui2/dialogs/quickview.py
+++ b/src/calibre/gui2/dialogs/quickview.py
@@ -785,8 +785,7 @@ class Quickview(QDialog, Ui_Quickview):
             self.book_not_in_view_error()
             return
         key = self.column_order[column]
-        modifiers = int(QApplication.keyboardModifiers())
-        if modifiers in (Qt.Modifier.CTRL, Qt.Modifier.SHIFT):
+        if QApplication.keyboardModifiers() in (Qt.KeyboardModifier.ControlModifier, Qt.KeyboardModifier.ShiftModifier):
             self.edit_metadata(book_id)
         else:
             self.view.select_cell(self.db.data.id_to_index(book_id),
diff --git a/src/calibre/gui2/keyboard.py b/src/calibre/gui2/keyboard.py
index 34f04001ab..456daae98f 100644
--- a/src/calibre/gui2/keyboard.py
+++ b/src/calibre/gui2/keyboard.py
@@ -32,17 +32,17 @@ class NameConflict(ValueError):
 
 
 def keysequence_from_event(ev):  # {{{
-    k, mods = ev.key(), int(ev.modifiers())
+    k, mods = ev.key(), ev.modifiers()
     if k in (
             0, Qt.Key.Key_unknown, Qt.Key.Key_Shift, Qt.Key.Key_Control, Qt.Key.Key_Alt,
             Qt.Key.Key_Meta, Qt.Key.Key_AltGr, Qt.Key.Key_CapsLock, Qt.Key.Key_NumLock,
             Qt.Key.Key_ScrollLock):
         return
     letter = QKeySequence(k).toString(QKeySequence.SequenceFormat.PortableText)
-    if mods & Qt.Modifier.SHIFT and letter.lower() == letter.upper():
+    if mods & Qt.KeyboardModifier.ShiftModifier and letter.lower() == letter.upper():
         # Something like Shift+* or Shift+> we have to remove the shift,
         # since it is included in keycode.
-        mods = mods & ~Qt.Modifier.SHIFT
+        mods = mods & ~Qt.KeyboardModifier.ShiftModifier
     return QKeySequence(k | mods)
 # }}}
 
diff --git a/src/calibre/gui2/library/alternate_views.py b/src/calibre/gui2/library/alternate_views.py
index 9c264f0df8..082911c200 100644
--- a/src/calibre/gui2/library/alternate_views.py
+++ b/src/calibre/gui2/library/alternate_views.py
@@ -51,7 +51,10 @@ class EncodeError(ValueError):
 def handle_enter_press(self, ev, special_action=None, has_edit_cell=True):
     if ev.key() in (Qt.Key.Key_Enter, Qt.Key.Key_Return):
         mods = ev.modifiers()
-        if mods & Qt.Modifier.CTRL or mods & Qt.Modifier.ALT or mods & Qt.Modifier.SHIFT or mods & Qt.Modifier.META:
+        if (
+            mods & Qt.KeyboardModifier.ControlModifier or mods & Qt.KeyboardModifier.AltModifier or
+            mods & Qt.KeyboardModifier.ShiftModifier or mods & Qt.KeyboardModifier.MetaModifier
+        ):
             return
         if self.state() != QAbstractItemView.State.EditingState and self.hasFocus() and self.currentIndex().isValid():
             from calibre.gui2.ui import get_gui
@@ -1151,7 +1154,8 @@ class GridView(QListView):
         return index
 
     def selectionCommand(self, index, event):
-        if event and event.type() == QEvent.Type.KeyPress and event.key() in (Qt.Key.Key_Home, Qt.Key.Key_End) and event.modifiers() & Qt.Modifier.CTRL:
+        if event and event.type() == QEvent.Type.KeyPress and event.key() in (Qt.Key.Key_Home, Qt.Key.Key_End
+                                    ) and event.modifiers() & Qt.KeyboardModifier.ControlModifier:
             return QItemSelectionModel.SelectionFlag.ClearAndSelect | QItemSelectionModel.SelectionFlag.Rows
         return super().selectionCommand(index, event)
 
diff --git a/src/calibre/gui2/library/views.py b/src/calibre/gui2/library/views.py
index 0278cfde71..9475c3e0a7 100644
--- a/src/calibre/gui2/library/views.py
+++ b/src/calibre/gui2/library/views.py
@@ -1205,7 +1205,8 @@ class BooksView(QTableView):  # {{{
         return index
 
     def selectionCommand(self, index, event):
-        if event and event.type() == QEvent.Type.KeyPress and event.key() in (Qt.Key.Key_Home, Qt.Key.Key_End) and event.modifiers() & Qt.Modifier.CTRL:
+        if event and event.type() == QEvent.Type.KeyPress and event.key() in (
+                Qt.Key.Key_Home, Qt.Key.Key_End) and event.modifiers() & Qt.KeyboardModifier.ControlModifier:
             return QItemSelectionModel.SelectionFlag.ClearAndSelect | QItemSelectionModel.SelectionFlag.Rows
         return super().selectionCommand(index, event)
 
diff --git a/src/calibre/gui2/metadata/diff.py b/src/calibre/gui2/metadata/diff.py
index a1bf87a0b4..d1e3bc96f7 100644
--- a/src/calibre/gui2/metadata/diff.py
+++ b/src/calibre/gui2/metadata/diff.py
@@ -646,7 +646,7 @@ class CompareMany(QDialog):
             b.clicked.connect(self.reject_all_remaining)
             self.sb = b = bb.addButton(_('R&eject'), QDialogButtonBox.ButtonRole.ActionRole)
             ac = QAction(self)
-            ac.setShortcut(QKeySequence(Qt.Modifier.ALT | Qt.Modifier.SHIFT | Qt.Key.Key_Right))
+            ac.setShortcut(QKeySequence(Qt.KeyboardModifier.AltModifier | Qt.KeyboardModifier.ShiftModifier | Qt.Key.Key_Right))
             ac.triggered.connect(b.click)
             self.addAction(ac)
             b.setToolTip(_('Reject changes and move to next [{}]').format(ac.shortcut().toString(QKeySequence.SequenceFormat.NativeText)))
@@ -655,7 +655,7 @@ class CompareMany(QDialog):
             if reject_button_tooltip:
                 b.setToolTip(reject_button_tooltip)
             self.next_action = ac = QAction(self)
-            ac.setShortcut(QKeySequence(Qt.Modifier.ALT | Qt.Key.Key_Right))
+            ac.setShortcut(QKeySequence(Qt.KeyboardModifier.AltModifier | Qt.Key.Key_Right))
             self.addAction(ac)
         if action_button is not None:
             self.acb = b = bb.addButton(action_button[0], QDialogButtonBox.ButtonRole.ActionRole)
diff --git a/src/calibre/gui2/tag_browser/view.py b/src/calibre/gui2/tag_browser/view.py
index ed74391c0c..f2e81bab9b 100644
--- a/src/calibre/gui2/tag_browser/view.py
+++ b/src/calibre/gui2/tag_browser/view.py
@@ -487,8 +487,7 @@ class TagsView(QTreeView):  # {{{
         set_to: if None, advance the state. Otherwise must be one of the values
         in TAG_SEARCH_STATES
         '''
-        modifiers = int(QApplication.keyboardModifiers())
-        exclusive = modifiers not in (Qt.Modifier.CTRL, Qt.Modifier.SHIFT)
+        exclusive = QApplication.keyboardModifiers() not in (Qt.KeyboardModifier.ControlModifier, Qt.KeyboardModifier.ShiftModifier)
         if self._model.toggle(index, exclusive, set_to=set_to):
             # Reset the focus back to TB if it has it before the toggle
             # Must ask this question before starting the search because
diff --git a/src/calibre/gui2/toc/main.py b/src/calibre/gui2/toc/main.py
index 2ffe1c84f9..c0f3f49cb0 100644
--- a/src/calibre/gui2/toc/main.py
+++ b/src/calibre/gui2/toc/main.py
@@ -641,16 +641,16 @@ class TreeWidget(QTreeWidget):  # {{{
                 item.setData(0, Qt.ItemDataRole.DisplayRole, fmt % (num + i))
 
     def keyPressEvent(self, ev):
-        if ev.key() == Qt.Key.Key_Left and ev.modifiers() & Qt.Modifier.CTRL:
+        if ev.key() == Qt.Key.Key_Left and ev.modifiers() & Qt.KeyboardModifier.ControlModifier:
             self.move_left()
             ev.accept()
-        elif ev.key() == Qt.Key.Key_Right and ev.modifiers() & Qt.Modifier.CTRL:
+        elif ev.key() == Qt.Key.Key_Right and ev.modifiers() & Qt.KeyboardModifier.ControlModifier:
             self.move_right()
             ev.accept()
-        elif ev.key() == Qt.Key.Key_Up and (ev.modifiers() & Qt.Modifier.CTRL or ev.modifiers() & Qt.Modifier.ALT):
+        elif ev.key() == Qt.Key.Key_Up and (ev.modifiers() & Qt.KeyboardModifier.ControlModifier or ev.modifiers() & Qt.KeyboardModifier.AltModifier):
             self.move_up()
             ev.accept()
-        elif ev.key() == Qt.Key.Key_Down and (ev.modifiers() & Qt.Modifier.CTRL or ev.modifiers() & Qt.Modifier.ALT):
+        elif ev.key() == Qt.Key.Key_Down and (ev.modifiers() & Qt.KeyboardModifier.ControlModifier or ev.modifiers() & Qt.KeyboardModifier.AltModifier):
             self.move_down()
             ev.accept()
         elif ev.key() in (Qt.Key.Key_Delete, Qt.Key.Key_Backspace):
@@ -663,7 +663,7 @@ class TreeWidget(QTreeWidget):  # {{{
         item = self.currentItem()
 
         def key(k):
-            sc = str(QKeySequence(k | Qt.Modifier.CTRL).toString(QKeySequence.SequenceFormat.NativeText))
+            sc = str(QKeySequence(k | Qt.KeyboardModifier.ControlModifier).toString(QKeySequence.SequenceFormat.NativeText))
             return ' [%s]'%sc
 
         if item is not None:
diff --git a/src/calibre/gui2/tweak_book/char_select.py b/src/calibre/gui2/tweak_book/char_select.py
index 1a8c92e6e9..3a92231cd1 100644
--- a/src/calibre/gui2/tweak_book/char_select.py
+++ b/src/calibre/gui2/tweak_book/char_select.py
@@ -806,7 +806,7 @@ class CharSelect(Dialog):
         self.raise_()
 
     def char_selected(self, c):
-        if QApplication.keyboardModifiers() & Qt.Modifier.CTRL:
+        if QApplication.keyboardModifiers() & Qt.KeyboardModifier.ControlModifier:
             self.hide()
         if self.parent() is None or self.parent().focusWidget() is None:
             QApplication.clipboard().setText(c)
diff --git a/src/calibre/gui2/tweak_book/completion/popup.py b/src/calibre/gui2/tweak_book/completion/popup.py
index 26d17009c9..d0f16d19b2 100644
--- a/src/calibre/gui2/tweak_book/completion/popup.py
+++ b/src/calibre/gui2/tweak_book/completion/popup.py
@@ -180,11 +180,11 @@ class ChoosePopupWidget(QWidget):
         if key == Qt.Key.Key_Escape:
             self.abort(), ev.accept()
             return True
-        if key == Qt.Key.Key_Tab and not ev.modifiers() & Qt.Modifier.CTRL:
+        if key == Qt.Key.Key_Tab and not ev.modifiers() & Qt.KeyboardModifier.ControlModifier:
             self.choose_next_result(previous=ev.modifiers() & Qt.KeyboardModifier.ShiftModifier)
             ev.accept()
             return True
-        if key == Qt.Key.Key_Backtab and not ev.modifiers() & Qt.Modifier.CTRL:
+        if key == Qt.Key.Key_Backtab and not ev.modifiers() & Qt.KeyboardModifier.ControlModifier:
             self.choose_next_result(previous=ev.modifiers() & Qt.KeyboardModifier.ShiftModifier)
             return True
         if key in (Qt.Key.Key_Up, Qt.Key.Key_Down):
diff --git a/src/calibre/gui2/tweak_book/editor/snippets.py b/src/calibre/gui2/tweak_book/editor/snippets.py
index 9d1b8f5bd1..547666a6d0 100644
--- a/src/calibre/gui2/tweak_book/editor/snippets.py
+++ b/src/calibre/gui2/tweak_book/editor/snippets.py
@@ -29,7 +29,7 @@ from polyglot.builtins import codepoint_to_chr, iteritems, itervalues
 
 string_length = lambda x: strlen(str(x))  # Needed on narrow python builds, as subclasses of unicode dont work
 KEY = Qt.Key.Key_J
-MODIFIER = Qt.Modifier.META if ismacos else Qt.Modifier.CTRL
+MODIFIER = Qt.KeyboardModifier.MetaModifier if ismacos else Qt.KeyboardModifier.ControlModifier
 
 SnipKey = namedtuple('SnipKey', 'trigger syntaxes')
 
diff --git a/src/calibre/gui2/tweak_book/editor/text.py b/src/calibre/gui2/tweak_book/editor/text.py
index 0e9bac6920..966ddb0761 100644
--- a/src/calibre/gui2/tweak_book/editor/text.py
+++ b/src/calibre/gui2/tweak_book/editor/text.py
@@ -811,7 +811,7 @@ class TextEdit(PlainTextEdit):
             # For some reason using eventFilter for this does not work, so we
             # implement it here
             self.completion_popup.abort()
-        if ev.modifiers() & Qt.Modifier.CTRL:
+        if ev.modifiers() & Qt.KeyboardModifier.ControlModifier:
             url = self.link_for_position(ev.pos())
             if url is not None:
                 ev.accept()