diff --git a/src/calibre/gui2/main.py b/src/calibre/gui2/main.py
index d736835fd6..4da06b22ae 100644
--- a/src/calibre/gui2/main.py
+++ b/src/calibre/gui2/main.py
@@ -345,6 +345,7 @@ def main(args=sys.argv):
         # On windows only singleinstance can be trusted
         otherinstance = True if iswindows else False
     if not otherinstance:
+        sys.setcheckinterval(50) # Make GUI more responsive
         return run_gui(opts, args, actions, listener, app)
 
     communicate(args)