diff --git a/src/calibre/ebooks/oeb/polish/check/css.py b/src/calibre/ebooks/oeb/polish/check/css.py
index ba9890a26d..ffe4f2bc21 100644
--- a/src/calibre/ebooks/oeb/polish/check/css.py
+++ b/src/calibre/ebooks/oeb/polish/check/css.py
@@ -16,7 +16,7 @@ from qt.webengine import (
 from calibre import detect_ncpus as cpu_count, prints
 from calibre.ebooks.oeb.polish.check.base import ERROR, WARN, BaseError
 from calibre.gui2 import must_use_qt
-from calibre.utils.webengine import secure_webengine
+from calibre.utils.webengine import secure_webengine, setup_profile
 
 
 class CSSParseError(BaseError):
@@ -116,6 +116,7 @@ def create_profile():
     ans = getattr(create_profile, 'ans', None)
     if ans is None:
         ans = create_profile.ans = QWebEngineProfile(QApplication.instance())
+        setup_profile(ans)
         s = QWebEngineScript()
         s.setName('csslint.js')
         s.setSourceCode(csslint_js())
diff --git a/src/calibre/ebooks/pdf/html_writer.py b/src/calibre/ebooks/pdf/html_writer.py
index fdd91cf7e4..b1d16f0db2 100644
--- a/src/calibre/ebooks/pdf/html_writer.py
+++ b/src/calibre/ebooks/pdf/html_writer.py
@@ -49,7 +49,7 @@ from calibre.utils.podofo import (
     dedup_type3_fonts, get_podofo, remove_unused_fonts, set_metadata_implementation
 )
 from calibre.utils.short_uuid import uuid4
-from calibre.utils.webengine import secure_webengine, send_reply
+from calibre.utils.webengine import secure_webengine, send_reply, setup_profile
 from polyglot.builtins import as_bytes, iteritems
 from polyglot.urllib import urlparse
 
@@ -352,6 +352,7 @@ class RenderManager(QObject):
         self.has_maths = {}
         self.interceptor.log = self.log = log
         ans = QWebEngineProfile(QApplication.instance())
+        setup_profile(ans)
         self.url_handler = UrlSchemeHandler(container, parent=ans)
         ans.installUrlSchemeHandler(QByteArray(FAKE_PROTOCOL.encode('ascii')), self.url_handler)
         ua = 'calibre-pdf-output ' + __version__
diff --git a/src/calibre/gui2/store/web_store.py b/src/calibre/gui2/store/web_store.py
index 14263f39b0..c1b1825c9c 100644
--- a/src/calibre/gui2/store/web_store.py
+++ b/src/calibre/gui2/store/web_store.py
@@ -9,10 +9,12 @@ from qt.core import (
     QApplication, QHBoxLayout, QIcon, QLabel, QProgressBar, QPushButton, QSize, QUrl,
     QVBoxLayout, QWidget, pyqtSignal
 )
-from qt.webengine import QWebEngineDownloadRequest, QWebEngineView
+from qt.webengine import (
+    QWebEngineDownloadRequest, QWebEnginePage, QWebEngineProfile, QWebEngineView
+)
 
 from calibre import random_user_agent, url_slash_cleaner
-from calibre.constants import STORE_DIALOG_APP_UID, cache_dir, islinux, iswindows
+from calibre.constants import STORE_DIALOG_APP_UID, islinux, iswindows
 from calibre.ebooks import BOOK_EXTENSIONS
 from calibre.gui2 import (
     Application, choose_save_file, error_dialog, gprefs, info_dialog, set_app_uid
@@ -21,6 +23,7 @@ from calibre.gui2.dialogs.confirm_delete import confirm
 from calibre.gui2.listener import send_message_in_process
 from calibre.gui2.main_window import MainWindow
 from calibre.ptempfile import PersistentTemporaryDirectory, reset_base_dir
+from calibre.utils.webengine import setup_profile
 from polyglot.binary import as_base64_bytes, from_base64_bytes
 from polyglot.builtins import string_or_bytes
 
@@ -75,6 +78,14 @@ class DownloadProgress(QWidget):
             self.setVisible(False)
 
 
+def create_profile():
+    ans = getattr(create_profile, 'ans', None)
+    if ans is None:
+        ans = create_profile.ans = setup_profile(QWebEngineProfile('web_store', QApplication.instance()))
+        ans.setHttpUserAgent(random_user_agent(allow_ie=False))
+    return ans
+
+
 class Central(QWidget):
 
     home = pyqtSignal()
@@ -83,10 +94,8 @@ class Central(QWidget):
         QWidget.__init__(self, parent)
         self.l = l = QVBoxLayout(self)
         self.view = v = QWebEngineView(self)
-        profile = v.page().profile()
-        profile.setCachePath(os.path.join(cache_dir(), 'web_store', 'hc'))
-        profile.setPersistentStoragePath(os.path.join(cache_dir(), 'web_store', 'ps'))
-        profile.setHttpUserAgent(random_user_agent(allow_ie=False))
+        self._page = QWebEnginePage(create_profile(), v)
+        v.setPage(self._page)
         v.loadStarted.connect(self.load_started)
         v.loadProgress.connect(self.load_progress)
         v.loadFinished.connect(self.load_finished)
diff --git a/src/calibre/gui2/toc/location.py b/src/calibre/gui2/toc/location.py
index c1ea20a676..fa825e6416 100644
--- a/src/calibre/gui2/toc/location.py
+++ b/src/calibre/gui2/toc/location.py
@@ -24,7 +24,7 @@ from calibre.gui2 import error_dialog, gprefs, is_dark_theme, question_dialog
 from calibre.gui2.palette import dark_color, dark_link_color, dark_text_color
 from calibre.utils.logging import default_log
 from calibre.utils.short_uuid import uuid4
-from calibre.utils.webengine import secure_webengine, send_reply
+from calibre.utils.webengine import secure_webengine, send_reply, setup_profile
 from polyglot.builtins import as_bytes
 
 
@@ -143,6 +143,7 @@ class Page(QWebEnginePage):  # {{{
         self.current_frag = None
         self.com_id = str(uuid4())
         profile = QWebEngineProfile(QApplication.instance())
+        setup_profile(profile)
         # store these globally as they need to be destructed after the QWebEnginePage
         current_container.url_handler = UrlSchemeHandler(parent=profile)
         current_container.interceptor = RequestInterceptor(profile)
diff --git a/src/calibre/gui2/tweak_book/preview.py b/src/calibre/gui2/tweak_book/preview.py
index 10e36b6229..fa7d1b1015 100644
--- a/src/calibre/gui2/tweak_book/preview.py
+++ b/src/calibre/gui2/tweak_book/preview.py
@@ -37,7 +37,8 @@ from calibre.gui2.webengine import RestartingWebEngineView
 from calibre.gui2.widgets2 import HistoryLineEdit2
 from calibre.utils.ipc.simple_worker import offload_worker
 from calibre.utils.webengine import (
-    Bridge, create_script, from_js, insert_scripts, secure_webengine, to_js
+    Bridge, create_script, from_js, insert_scripts, secure_webengine, setup_profile,
+    to_js
 )
 from polyglot.builtins import iteritems
 from polyglot.queue import Empty, Queue
@@ -294,6 +295,7 @@ def create_profile():
     ans = getattr(create_profile, 'ans', None)
     if ans is None:
         ans = QWebEngineProfile(QApplication.instance())
+        setup_profile(ans)
         ua = 'calibre-editor-preview ' + __version__
         ans.setHttpUserAgent(ua)
         if is_running_from_develop:
@@ -391,6 +393,7 @@ class Inspector(QWidget):
     def visibility_changed(self, visible):
         if visible and self.view is None:
             self.view = QWebEngineView(self.view_to_debug)
+            setup_profile(self.view.page().profile())
             self.view_to_debug.page().setDevToolsPage(self.view.page())
             self.layout.addWidget(self.view)
 
diff --git a/src/calibre/gui2/viewer/lookup.py b/src/calibre/gui2/viewer/lookup.py
index 5b2acaac8c..c4adbbe5db 100644
--- a/src/calibre/gui2/viewer/lookup.py
+++ b/src/calibre/gui2/viewer/lookup.py
@@ -2,24 +2,24 @@
 # License: GPL v3 Copyright: 2019, Kovid Goyal <kovid at kovidgoyal.net>
 
 
-import os
 import sys
 import textwrap
 from qt.core import (
-    QApplication, QCheckBox, QComboBox, QDialog, QDialogButtonBox, QFormLayout, QAbstractItemView,
-    QHBoxLayout, QIcon, QLabel, QLineEdit, QListWidget, QListWidgetItem, QPushButton,
-    QSize, Qt, QTimer, QUrl, QVBoxLayout, QWidget, pyqtSignal
+    QAbstractItemView, QApplication, QCheckBox, QComboBox, QDialog, QDialogButtonBox,
+    QFormLayout, QHBoxLayout, QIcon, QLabel, QLineEdit, QListWidget, QListWidgetItem,
+    QPushButton, QSize, Qt, QTimer, QUrl, QVBoxLayout, QWidget, pyqtSignal
 )
 from qt.webengine import (
     QWebEnginePage, QWebEngineProfile, QWebEngineScript, QWebEngineView
 )
 
 from calibre import prints, random_user_agent
-from calibre.constants import cache_dir
 from calibre.gui2 import error_dialog
 from calibre.gui2.viewer.web_view import apply_font_settings, vprefs
-from calibre.utils.webengine import create_script, insert_scripts, secure_webengine
 from calibre.gui2.widgets2 import Dialog
+from calibre.utils.webengine import (
+    create_script, insert_scripts, secure_webengine, setup_profile
+)
 
 vprefs.defaults['lookup_locations'] = [
     {
@@ -191,7 +191,7 @@ def create_profile():
     if ans is None:
         ans = QWebEngineProfile('viewer-lookup', QApplication.instance())
         ans.setHttpUserAgent(random_user_agent(allow_ie=False))
-        ans.setCachePath(os.path.join(cache_dir(), 'ev2vl'))
+        setup_profile(ans)
         js = P('lookup.js', data=True, allow_user_override=False)
         insert_scripts(ans, create_script('lookup.js', js, injection_point=QWebEngineScript.InjectionPoint.DocumentCreation))
         s = ans.settings()
@@ -305,6 +305,7 @@ class Lookup(QWidget):
             self._devtools_page = QWebEnginePage()
             self._devtools_view = QWebEngineView(self)
             self._devtools_view.setPage(self._devtools_page)
+            setup_profile(self._devtools_page.profile())
             self._page.setDevToolsPage(self._devtools_page)
             self._devtools_dialog = d = QDialog(self)
             d.setWindowTitle('Inspect Lookup page')
diff --git a/src/calibre/gui2/viewer/web_view.py b/src/calibre/gui2/viewer/web_view.py
index c2c009ea28..9ec216ed3c 100644
--- a/src/calibre/gui2/viewer/web_view.py
+++ b/src/calibre/gui2/viewer/web_view.py
@@ -34,7 +34,7 @@ from calibre.utils.serialize import json_loads
 from calibre.utils.shared_file import share_open
 from calibre.utils.webengine import (
     Bridge, create_script, from_js, insert_scripts, secure_webengine, send_reply,
-    to_js
+    to_js, setup_profile
 )
 from polyglot.builtins import as_bytes, iteritems
 from polyglot.functools import lru_cache
@@ -183,7 +183,7 @@ class UrlSchemeHandler(QWebEngineUrlSchemeHandler):
 def create_profile():
     ans = getattr(create_profile, 'ans', None)
     if ans is None:
-        ans = QWebEngineProfile(QApplication.instance())
+        ans = setup_profile(QWebEngineProfile(QApplication.instance()))
         osname = 'windows' if iswindows else ('macos' if ismacos else 'linux')
         # DO NOT change the user agent as it is used to workaround
         # Qt bugs see workaround_qt_bug() in ajax.pyj
@@ -399,6 +399,7 @@ class Inspector(QWidget):
     def visibility_changed(self, visible):
         if visible and self.view is None:
             self.view = QWebEngineView(self.view_to_debug)
+            setup_profile(self.view.page().profile())
             self.view_to_debug.page().setDevToolsPage(self.view.page())
             self.layout.addWidget(self.view)
 
diff --git a/src/calibre/scraper/simple_backend.py b/src/calibre/scraper/simple_backend.py
index ca389cea6f..025f6571b9 100644
--- a/src/calibre/scraper/simple_backend.py
+++ b/src/calibre/scraper/simple_backend.py
@@ -3,7 +3,6 @@
 # License: GPL v3 Copyright: 2022, Kovid Goyal <kovid at kovidgoyal.net>
 
 import json
-import os
 import secrets
 import sys
 import time
@@ -11,8 +10,7 @@ from functools import lru_cache
 from qt.core import QApplication, QEventLoop, QUrl
 from qt.webengine import QWebEnginePage, QWebEngineProfile, QWebEngineSettings
 
-from calibre.constants import cache_dir
-from calibre.utils.webengine import create_script, insert_scripts
+from calibre.utils.webengine import create_script, insert_scripts, setup_profile
 
 
 def canonicalize_qurl(qurl):
@@ -29,9 +27,9 @@ def create_profile(cache_name='', allow_js=False):
     from calibre.utils.random_ua import random_common_chrome_user_agent
     if cache_name:
         ans = QWebEngineProfile(cache_name, QApplication.instance())
-        ans.setCachePath(os.path.join(cache_dir(), 'scraper', cache_name))
     else:
         ans = QWebEngineProfile(QApplication.instance())
+    setup_profile(ans)
     ans.setHttpUserAgent(random_common_chrome_user_agent())
     ans.setHttpCacheMaximumSize(0)  # managed by webengine
     s = ans.settings()
diff --git a/src/calibre/test_build.py b/src/calibre/test_build.py
index c0f5029216..e8364ab9ee 100644
--- a/src/calibre/test_build.py
+++ b/src/calibre/test_build.py
@@ -320,6 +320,7 @@ class BuildTest(unittest.TestCase):
         test()
 
         from calibre.gui2 import ensure_app, destroy_app
+        from calibre.utils.webengine import setup_profile
         display_env_var = os.environ.pop('DISPLAY', None)
         try:
             ensure_app()
@@ -333,6 +334,7 @@ class BuildTest(unittest.TestCase):
             na = QNetworkAccessManager()
             self.assertTrue(hasattr(na, 'sslErrors'), 'Qt not compiled with openssl')
             p = QWebEnginePage()
+            setup_profile(p.profile())
 
             def callback(result):
                 callback.result = result
diff --git a/src/calibre/utils/rapydscript.py b/src/calibre/utils/rapydscript.py
index 1768a6898c..747ee74272 100644
--- a/src/calibre/utils/rapydscript.py
+++ b/src/calibre/utils/rapydscript.py
@@ -59,7 +59,7 @@ def compiler():
 
     from calibre import walk
     from calibre.gui2 import must_use_qt
-    from calibre.utils.webengine import secure_webengine, setup_default_profile
+    from calibre.utils.webengine import secure_webengine, setup_default_profile, setup_profile
     must_use_qt()
     setup_default_profile()
 
@@ -126,6 +126,7 @@ document.title = 'compiler initialized';
 
         def __init__(self):
             super().__init__()
+            setup_profile(self.profile())
             self.errors = []
             secure_webengine(self)
             script = compiler_script
@@ -342,9 +343,10 @@ def run_rapydscript_tests():
     from calibre.gui2 import must_use_qt
     from calibre.gui2.viewer.web_view import send_reply
     from calibre.utils.webengine import (
-        create_script, insert_scripts, secure_webengine
+        create_script, insert_scripts, secure_webengine, setup_default_profile, setup_profile
     )
     must_use_qt()
+    setup_default_profile()
     scheme = QWebEngineUrlScheme(FAKE_PROTOCOL.encode('ascii'))
     scheme.setSyntax(QWebEngineUrlScheme.Syntax.Host)
     scheme.setFlags(QWebEngineUrlScheme.Flag.SecureScheme)
@@ -388,6 +390,7 @@ def run_rapydscript_tests():
         def __init__(self):
             profile = QWebEngineProfile(QApplication.instance())
             profile.setHttpUserAgent('calibre-tester')
+            setup_profile(profile)
             insert_scripts(profile, create_script('test-rapydscript.js', js, on_subframes=False))
             url_handler = UrlSchemeHandler(profile)
             profile.installUrlSchemeHandler(QByteArray(FAKE_PROTOCOL.encode('ascii')), url_handler)
diff --git a/src/calibre/utils/webengine.py b/src/calibre/utils/webengine.py
index 3d036c67e8..1b6b3bbfcd 100644
--- a/src/calibre/utils/webengine.py
+++ b/src/calibre/utils/webengine.py
@@ -10,11 +10,20 @@ from qt.webengine import QWebEngineScript, QWebEngineSettings, QWebEngineProfile
 from calibre.constants import cache_dir, SPECIAL_TITLE_FOR_WEBENGINE_COMMS
 
 
+def setup_profile(profile):
+    # Qt uses persistent storage path to store cached GPU data even for OTR profiles
+    base = os.path.abspath(os.path.join(cache_dir(), 'qwe', profile.storageName() or 'dp'))
+    cp = os.path.join(base, 'c')
+    if profile.cachePath() != cp:
+        profile.setCachePath(cp)
+    sp = os.path.join(base, 'sp')
+    if profile.persistentStoragePath() != sp:
+        profile.setPersistentStoragePath(sp)
+    return profile
+
+
 def setup_default_profile():
-    p = QWebEngineProfile.defaultProfile()
-    q = os.path.join(cache_dir(), 'qt-webeng')
-    if p.cachePath() != q:
-        p.setCachePath(q)
+    return setup_profile(QWebEngineProfile.defaultProfile())
 
 
 def send_reply(rq, mime_type, data):