diff --git a/src/calibre/ebooks/metadata/opf.py b/src/calibre/ebooks/metadata/opf.py
index e4a88580ae..5211d349e4 100644
--- a/src/calibre/ebooks/metadata/opf.py
+++ b/src/calibre/ebooks/metadata/opf.py
@@ -46,10 +46,18 @@ def set_metadata_opf2(root, cover_prefix, mi, opf_version, cover_data=None, appl
         opf.timestamp = mi.timestamp
     raster_cover = opf.raster_cover
     if raster_cover is None and cover_data is not None:
-        if cover_prefix and not cover_prefix.endswith('/'):
-            cover_prefix += '/'
-        name = cover_prefix + 'cover.jpg'
-        i = create_manifest_item(opf.root, name, 'cover')
+        guide_raster_cover = opf.guide_raster_cover
+        i = None
+        if guide_raster_cover is not None:
+            i = guide_raster_cover
+            raster_cover = i.get('href')
+        else:
+            if cover_prefix and not cover_prefix.endswith('/'):
+                cover_prefix += '/'
+            name = cover_prefix + 'cover.jpg'
+            i = create_manifest_item(opf.root, name, 'cover')
+            if i is not None:
+                raster_cover = name
         if i is not None:
             if opf_version.major < 3:
                 [x.getparent().remove(x) for x in opf.root.xpath('//*[local-name()="meta" and @name="cover"]')]
@@ -59,7 +67,6 @@ def set_metadata_opf2(root, cover_prefix, mi, opf_version, cover_data=None, appl
                 for x in opf.root.xpath('//*[local-name()="item" and contains(@properties, "cover-image")]'):
                     x.set('properties', x.get('properties').replace('cover-image', '').strip())
                 i.set('properties', 'cover-image')
-            raster_cover = name
 
     with pretty_print:
         return opf.render(), raster_cover
diff --git a/src/calibre/ebooks/metadata/opf2.py b/src/calibre/ebooks/metadata/opf2.py
index 9a3868b428..674ce387e5 100644
--- a/src/calibre/ebooks/metadata/opf2.py
+++ b/src/calibre/ebooks/metadata/opf2.py
@@ -523,6 +523,7 @@ class OPF(object):  # {{{
     pubdate_path    = XPath('descendant::*[re:match(name(), "date", "i")]')
     raster_cover_path = XPath('descendant::*[re:match(name(), "meta", "i") and ' +
             're:match(@name, "cover", "i") and @content]')
+    guide_cover_path = XPath('descendant::*[local-name()="guide"]/*[local-name()="reference" and re:match(@type, "cover", "i")]/@href')
     identifier_path = XPath('descendant::*[re:match(name(), "identifier", "i")]')
     application_id_path = XPath('descendant::*[re:match(name(), "identifier", "i") and '+
                             '(re:match(@opf:scheme, "calibre|libprs500", "i") or re:match(@scheme, "calibre|libprs500", "i"))]')
@@ -1173,6 +1174,19 @@ class OPF(object):  # {{{
                     if mt and 'xml' not in mt and 'html' not in mt:
                         return item.get('href', None)
 
+    @property
+    def guide_raster_cover(self):
+        covers = self.guide_cover_path(self.root)
+        if covers:
+            mt_map = {i.get('href'):i for i in self.itermanifest()}
+            for href in covers:
+                if href:
+                    i = mt_map.get(href)
+                    if i is not None:
+                        iid, mt = i.get('id'), i.get('media-type')
+                        if iid and mt and mt.lower() in {'image/png', 'image/jpeg', 'image/jpg', 'image/gif'}:
+                            return i
+
     @property
     def epub3_nav(self):
         if self.package_version >= 3.0: